In the chaotic aftermath of a genetically modified sea monster's escape, an American scientist must confront his own creation when a hybrid pterodactyl-barracuda creature begins to wreak havoc on populated areas. A desperate marine biologist teams up with a military commando to stop the new threat and reclaim her monstrous offspring. As death tolls rise and chaos ensues, the two forces are forced into an uneasy alliance to take down both the Sharktopus and its deadly nemesis, Pteracuda.