"McBride: Tune in for Murder" follows Mike McBride (John Larroquette), a detective investigating the murder of radio star Ron Garrison (Frazer Smith) and the subsequent arrest of his co-host Bob Carter (John Kapelos). As McBride delves into the case, he teams up with Sgt. Roberta Hansen (Marta DuBois) to uncover the truth behind the crime. The investigation uncovers a web of unanswered questions surrounding Ron's murder, leading to a re-examination of the evidence and Bob's guilt.