In a world ravaged by an epidemic of blindness, a small group of survivors band together to overcome the horrific conditions of their imposed quarantine in a derelict asylum. Julianne Moore plays Doctor's Wife, a woman whose sight is kept secret as she struggles with her isolation and responsibility towards others. Mark Ruffalo stars as the doctor, who becomes a leader among his fellow inmates, and ultimately finds solace in his admiration for his wife's strength. As society collapses around them, the group faces unimaginable challenges, including violence, desperation, and despair, but also discovers moments of hope and resilience.