Cate DeAngelo (Mary-Louise Parker) runs a struggling vintage clothing store in Washington D.C., while her relationship with fiancé Philip lacks passion. Her sister Francesca introduces her to Harry Dietrich (Peter Gallagher), a charming lawyer who shows Cate how to relax and enjoy life, leading to a whirlwind romance and marriage. However, their happiness is short-lived as Harry's cancer diagnosis sets in, testing the couple's love for each other.