Mojo Nixon's life story is told through a humorous and unconventional biography that follows his journey from a young man on a bicycle trip across America to mainstream success during the Golden Age of MTV. Along the way, he teams up with fellow musicians Skid Roper, Kinky Friedman, Todd Snider, and John Doe, who all contribute to his unique persona as Mojo Nixon. Winona Ryder also makes an appearance in this documentary-style film, which explores the eccentricities and charm of its subject.