Three years after their last adventure, Natalie Cook (Cameron Diaz), Dylan Sanders (Drew Barrymore), and Alex Munday (Lucy Liu) are sent to recover stolen rings that can display witness protection program information, targeting a rogue agent who might be responsible for the killings of informants. The Angels team up with Jimmy Bosley (Bernie Mac) and former Angel Madison Lee (Demi Moore) to track down the mastermind behind the thefts. Along the way, they uncover a web of organized crime and deception that leads them to a showdown at the Hollywood Walk of Fame.