A friendly St. Bernard named Cujo contracts rabies and conducts a reign of terror on a small American town. Donna Trenton (Dee Wallace) and her young son Tad Trenton are trapped inside their car while protecting themselves from the infected dog, which is driven mad by a bat bite. As the situation escalates, Vic Trenton returns home to find his house vandalized and his wife missing, with only his son left for him to rescue in a desperate bid for survival.
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