Brittany Forgler (Jillian Bell), a 28-year-old living in NYC, receives a startling wake-up call from her doctor and sets out to lose weight and train for the city's annual marathon. She joins a group run with her neighbor Catherine (Michaela Watkins) and meets Seth (Utkarsh Ambudkar), another struggling runner, bonding over their goals. As Brittany seeks a second job, becomes a pet sitter in a wealthy home, and faces setbacks, she finds inspiration from those around her and ultimately pushes through to finish the marathon.
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