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Ben Campbell (Jim Sturgess) is a highly intelligent student at M.I.T. who strives to succeed and become a doctor at Harvard School of Medicine. He joins the MIT Blackjack Team, led by Professor Rosa (Kevin Spacey), where they use card counting and covert signalling to increase their probability of winning at casinos. The team's success earns them substantial profits, but also attracts unwanted attention from casino security and law enforcement, leading to a cat-and-mouse game with Ben and his teammates.