The documentary follows director Mark Wexler on a three-year pilgrimage to discover the best practices and philosophies to help mitigate old age. He interviews an eclectic group of celebrities, health care professionals, centenarians, followers of Laughter Yoga, and scientists, including Ray Kurzweil, Aubrey de Grey, Jack LaLanne (as himself), Suzanne Somers (as herself), Phyllis Diller (as herself), Pierre Jean Buster Martin (as himself), Jonathan Gold (as himself), Dr. Madan Kataria (as himself), Eleanor Wasson (as herself), and Pico Iyer (as himself).
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