A group of humans arrive on Sirius 6-B to investigate an SOS signal, finding a few human survivors in an old military outpost after supposedly being deserted by the "screamers." The team must survive against a deadly alien threat where three of their own are killed and transformed into cyborgs. Lt. Victoria Bronte (Gina Holden) eventually discovers two remaining Screamers and helps her team destroy them, but not before they're nearly overwhelmed by an unexpected group of hybrid creatures created from human and Screamer DNA.
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