After waking up in a hospital with amnesia, professor Robert Langdon and doctor Dr. Sienna Brooks race against time to foil a deadly global plot. They soon realize this is the first clue in a trail left by the radical, transhumanist genius scientist Bertrand Zobrist, who believed that rigorous measures were necessary to reduce the Earth's growing population. Along the way, Langdon and Brooks figure out that Zobrist has created a biological superweapon dubbed "Inferno", with the potential of annihilating half the world's population.
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