A group of childhood friends, including Doug McCallister (Jack Black) and Ronald "Griff" Griffin Jr. (Paul Rudd), travel to the Amazon Rainforest in Brazil to make a low-budget indie version of their favorite film, Anaconda. The group's endeavor is soon derailed when they accidentally awaken a massive anaconda, leading to chaos and terror. As they try to survive and complete their film, they encounter violent criminals, natural disasters, and each other's personal demons, all while navigating the absurdity of indie filmmaking.
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