A young film trailer editor, Sean (Kerr Smith), picks up a shady hitchhiker, Nick (Brendan Fehr), who is a vampire hunter tracking a group of vampires known as the Forsaken. As they cross-country drive through Arizona, they encounter a disoriented young woman, Megan (Izabella Miko), being stalked by a vampire cult. Sean and Nick team up to find a cure for their vampirism after Sean gets bitten by one of the Forsaken, leading them on a road trip to an old Spanish mission where they hope to kill the responsible vampire and break the curse.
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