Alice Klieg (Kristen Wiig), a mentally ill single woman living on disability benefits and fan of Oprah Winfrey, wins the California lottery jackpot of $86 million. She appears on the local TV news celebrating her win but is upset when the speech she prepared is abruptly cut off after she mentions using masturbation as a sedative. After discontinuing her medication, Alice moves into a casino hotel with her best friend Gina Selway and hijacks a live-broadcast to propose her idea for a talk show titled "Welcome to Me." As her show grows in popularity, her friends and family become alienated by her non-flattering depictions of them in her sketches.
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