Best friends Bud "Squirrel" Macintosh and Doyle "Stubs" Johnson, two environmentally-challenged slackers, accidentally stumble into a science experiment when they mistake a futuristic bio-dome for a mall, sealing themselves inside with a group of scientists for a year. As they bumble their way through the dome's closed ecosystem, they inadvertently sabotage the experiment and cause chaos, leading to an unexpected team-up with the very people they initially annoyed. Through a series of misadventures, Bud and Doyle learn to restore balance to the Bio-Dome, while also bonding with their scientists counterparts and outdoing them at an environmental party.
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