Philo Beddoe is back in action as he reluctantly returns to bare-knuckle boxing after deciding to retire from the sport. When the Mafia makes him an offer he cannot refuse, Philo must take on a new fight to pay off his debts, but things get complicated when an old flame and a motorcycle gang are involved. Along the way, Philo's trusty sidekick Clyde the orangutan causes chaos and hilarity ensues in this fun and action-packed sequel to Every Which Way But Loose.